.Nature Medication, Posted online: 18 September 2024 doi:10.1038/ s41591-024-03300-3Genomic as well as epidemiologic reviews uncovered that an unfamiliar reassortant viral lineage of the Oropouche virus, which has been spreading in the western Amazon region of Brazil for regarding a many years, is related to the recent individual break outs between 2022 as well as 2024.